Design and properties of novel Ti–Zr–Hf–Nb–Ta high-entropy alloys for biomedical applications

The novel high-entropy alloys (HEAs) with compositions of (Ti1/3Zr1/3Hf1/3)15(Nb1/2Ta1/2)x (x = 3, 5) for biomedical applications have been designed and synthesized, using the cluster formula approach. present HEAs a single body-centered-cubic (BCC) solid-solution structure possess prominent mechanical properties high compressive yield strength (834–890 MPa) microhardness (287–293 Hv), large plasticity (>45%) under compression, as well low Young's moduli (56–68 GPa). Also, these exhibit good bio-corrosion resistance, revealed by corrosion rate at order 10?4 mm/year passive current densities 10?2 – 10?1 A/m2, which are attributed to formation films consisting Ti-, Zr-, Hf-, Nb-, Ta- oxides. cell viability proliferation bone-forming MC3T3-E1 cells on comparable those Ti–6Al–4V alloy, indicating their biocompatibility. work demonstrates great potential Ti–Zr–Hf–Nb–Ta applications.